Stony Brook University - Department of Molecular Genetics & Microbiology

Journal Articles.

Mueller, S., and R. J. Simpson. 1994. Photoreduction of iron at physiological pH: Effect of biological buffers. Biochem. Soc. Trans. 22:93S.
Gromeier, M., Mueller, S., Solecki, D., Bossert, Bernhardt, G., Wimmer, E. 1997. Determinants of poliovirus neurovirulence. J. Neurovirol. 3:35-38
Mueller, S., Wimmer, E. 1998. Expression of foreign proteins by poliovirus polyprotein fusion:Analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames. J. Virol. 72:20-31.
He, Y., V. D. Borman, V. D.*, Mueller, S.*, Bator, C., Bella, J., Peng, X., Baker, T. S., Wimmer, E., Kuhn, R. J., Rossmann, M. G. 2000. Interaction of the poliovirus receptor with poliovirus. Proc. Natl. Acad. Sci. USA. 97: 79-84.
Li, X., Lu, H. H., Mueller, S., Wimmer, E. 2001. The C-terminal residues of poliovirus proteinase 2Apro are critical for viral RNA replication but not for cis- and trans-proteolytic cleavages. J. Gen.Virol. 82: 397-408
Mueller, S., Cao, X. Welker, R., Wimmer, E. 2002. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. J. Biol. Chem. 277(10): 7897-904.
Solecki, D. J., Gromeier, M., Mueller, S., Bernhardt, G., Wimmer, E. 2002. Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. J. Biol. Chem. 277(28):25697-702
Ozaki-Kuroda, K., Nakanishi, H., Ohta, H., Tanaka, H., Kurihara, H., Mueller, S., Irie, K., Ikeda, W., Sakai, T., Wimmer, E., Nishimune, Y., and Y. Takai. 2002. Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr. Biol. 12(13):1145-50
Iwasaki, A., Welker, R., Mueller, S., Linehan, M., Nomoto, A., Wimmer, E. 2002. Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer's Patches of Humans, Primates and CD155 Transgenic Mice: Implications for Poliovirus Infection. J. Inf. Disease. 186(5): 585-92.
He, Y., Mueller, S., Chipman, P. R., Bator C. M., Bowman, V., Mukhopadhyay, S., Wimmer, E., Kuhn, R. J., Rossmann, M. G. 2003. Complexes of poliovirus serotypes with their common cellular receptor PVR. J. Virol. 77:4827-4835 (2003).
Mueller, S., Rosenquist T. A., Takai, Y., Bronson, R. A., and E. Wimmer. Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biol. Of Reprod. 69:(4)1330-1340 (2003).
Mueller, S., and E. Wimmer. 2003. Recruitment of nectin-3 to cell-cell junctions through transheterophilic interaction with CD155, a vitronectin receptor expressed in alpha(v)beta(3) integrin containing microdomains. J. Biol. Chem. 278:(33):31251-31260.
Mueller S, Wimmer E, J.Cello. 2005. Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event. Virus Res. 111(2):175-93.
Mueller, S, Jiang, P., Rieder, E., DeJesus, N., Iwasaki, A., Cello, J., Wimmer, E. 2005. Pathogenesis and prevention of poliomyelitis and the chemical synthesis of poliovirus. Nova Acta Leopol. 92(344): 35-43
Cohn CA, Mueller S, Wimmer E, Leifer N, Greenbaum S, Strongin DR, Schoonen MA. 2006. Pyrite-induced hydroxyl radical formation and its effect on nucleic acids. Geochem Trans. 7:3.
Mueller, S., Papamichail, D., Coleman, J.R., Skiena, S., and E. Wimmer. 2006. Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity. J. Virol. 80(19):9687-96.
Papamichael, D., Wang, B., Mueller, S., Skiena, S. 2006. Two proteins for the price of one: The design of maximally compressed coding sequences, Lecture Notes in Computer Science, 3892:387-98
Toyoda H, Yin J, Mueller S, Wimmer E, Cello J. 2007. Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model. Cancer Res. 67(6):2857-64
Coleman J. R., Papamichail D, Skiena S, Futcher B, Wimmer E, and S. Mueller. 2008. Virus attenuation by genome-scale changes in codon pair bias. Science 320(5884):1784-7.
Zhang P*, Mueller S*, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG. 2008. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc. Natl. Acad. Sci. USA. 105(47):18284-9.
Mueller S, Coleman JR, Wimmer E. Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis. 2009. Chem Biol. 16(3):337-47
Satomi-Kobayashi, S., Ueyama, T., Mueller, S., Toh, R., Masano, T., Sakoda, T., et al. 2009. Deficiency of Nectin-2 Leads to Cardiac Fibrosis and Dysfunction Under Chronic Pressure Overload. Hypertension 54(4):825-31. Epub 2009 Aug 10. PubMed PMID:19667252.
Li, X., Mueller, S., Wimmer, E. 2009. Inhibition of Hepatitis C Virus IRES-mediated Translation by Oligonucleotides. Virus Res. 2009 Aug 28. [Epub ahead of print] PubMed PMID: 19720092.
Wimmer, E., Mueller, S., Tumpey, T. M., J. K. Taubenberger. 2009. Synthetic viruses: a new opportunity to understand and prevent viral disease. Nature Biotechnol. 27(12):1163-72.

Books

Gromeier, M., Lu, H. H., Mueller, S., Alexander, L., Wimmer, E.. 1997. Attenuated poliovirus as live vaccine. In M. Levine (ed.), New Generation Vaccines. Marcel Dekker Inc., New York.
Mueller, S., Wimmer, E. 2000. Picornaviruses as tools of antigen delivery. In A. Cid-Arregui and A. Garcia-Carranca (eds.), Viral Vectors in Gene Therapy and Basic Research. Eaton Publishing, Natick, Massachusetts.
Mueller, S., and E. Wimmer. 2007. Picornavirus based expression vectors. In Friedmann, T., Rossi, J. (eds.) Gene Transfer: Delivery and Expression of DNA and RNA. Cold Spring Harbor Press, Cold Spring Harbor, NY
Mueller, S., Coleman, J.R., Cello, J., Paul, A., and E. Wimmer. 2007. Synthetic Biology: Synthesis and modification of a chemical called poliovirus. In Luryi, S., Xu, J., Zaslawsky, A. (eds.) Future Trends in Microelectronics: Up the Nano Creek. Wiley & Sons, Inc., Hoboken, New Jersey.

In the News

2000

Study reveals family secret of how viruses enter cells (Purdue News).


	Steffen Mueller PubMed Click here to view current publications on PubMed. Publications Journal Articles. Mueller, S., and R. J. Simpson. 1994. Photoreduction of iron at physiological pH: Effect of biological buffers. Biochem. Soc. Trans. 22:93S. Gromeier, M., Mueller, S., Solecki, D., Bossert, Bernhardt, G., Wimmer, E. 1997. Determinants of poliovirus neurovirulence. J. Neurovirol. 3:35-38 Mueller, S., Wimmer, E. 1998. Expression of foreign proteins by poliovirus polyprotein fusion:Analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames. J. Virol. 72:20-31. He, Y., V. D. Borman, V. D., Mueller, S., Bator, C., Bella, J., Peng, X., Baker, T. S., Wimmer, E., Kuhn, R. J., Rossmann, M. G. 2000. Interaction of the poliovirus receptor with poliovirus. Proc. Natl. Acad. Sci. USA. 97: 79-84. Li, X., Lu, H. H., Mueller, S., Wimmer, E. 2001. The C-terminal residues of poliovirus proteinase 2Apro are critical for viral RNA replication but not for cis- and trans-proteolytic cleavages. J. Gen.Virol. 82: 397-408 Mueller, S., Cao, X. Welker, R., Wimmer, E. 2002. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. J. Biol. Chem. 277(10): 7897-904. Solecki, D. J., Gromeier, M., Mueller, S., Bernhardt, G., Wimmer, E. 2002. Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. J. Biol. Chem. 277(28):25697-702 Ozaki-Kuroda, K., Nakanishi, H., Ohta, H., Tanaka, H., Kurihara, H., Mueller, S., Irie, K., Ikeda, W., Sakai, T., Wimmer, E., Nishimune, Y., and Y. Takai. 2002. Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr. Biol. 12(13):1145-50 Iwasaki, A., Welker, R., Mueller, S., Linehan, M., Nomoto, A., Wimmer, E. 2002. Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer's Patches of Humans, Primates and CD155 Transgenic Mice: Implications for Poliovirus Infection. J. Inf. Disease. 186(5): 585-92. He, Y., Mueller, S., Chipman, P. R., Bator C. M., Bowman, V., Mukhopadhyay, S., Wimmer, E., Kuhn, R. J., Rossmann, M. G. 2003. Complexes of poliovirus serotypes with their common cellular receptor PVR. J. Virol. 77:4827-4835 (2003). Mueller, S., Rosenquist T. A., Takai, Y., Bronson, R. A., and E. Wimmer. Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biol. Of Reprod. 69:(4)1330-1340 (2003). Mueller, S., and E. Wimmer. 2003. Recruitment of nectin-3 to cell-cell junctions through transheterophilic interaction with CD155, a vitronectin receptor expressed in alpha(v)beta(3) integrin containing microdomains. J. Biol. Chem. 278:(33):31251-31260. Mueller S, Wimmer E, J.Cello. 2005. Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event. Virus Res. 111(2):175-93. Mueller, S, Jiang, P., Rieder, E., DeJesus, N., Iwasaki, A., Cello, J., Wimmer, E. 2005. Pathogenesis and prevention of poliomyelitis and the chemical synthesis of poliovirus. Nova Acta Leopol. 92(344): 35-43 Cohn CA, Mueller S, Wimmer E, Leifer N, Greenbaum S, Strongin DR, Schoonen MA. 2006. Pyrite-induced hydroxyl radical formation and its effect on nucleic acids. Geochem Trans. 7:3. Mueller, S., Papamichail, D., Coleman, J.R., Skiena, S., and E. Wimmer. 2006. Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity. J. Virol. 80(19):9687-96. Papamichael, D., Wang, B., Mueller, S., Skiena, S. 2006. Two proteins for the price of one: The design of maximally compressed coding sequences, Lecture Notes in Computer Science, 3892:387-98 Toyoda H, Yin J, Mueller S, Wimmer E, Cello J. 2007. Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model. Cancer Res. 67(6):2857-64 Coleman J. R., Papamichail D, Skiena S, Futcher B, Wimmer E, and S. Mueller. 2008. Virus attenuation by genome-scale changes in codon pair bias. Science 320(5884):1784-7. Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG. 2008. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc. Natl. Acad. Sci. USA. 105(47):18284-9. Mueller S, Coleman JR, Wimmer E. Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis. 2009. Chem Biol. 16(3):337-47 Satomi-Kobayashi, S., Ueyama, T., Mueller, S., Toh, R., Masano, T., Sakoda, T., et al. 2009. Deficiency of Nectin-2 Leads to Cardiac Fibrosis and Dysfunction Under Chronic Pressure Overload. Hypertension 54(4):825-31. Epub 2009 Aug 10. PubMed PMID:19667252. Li, X., Mueller, S., Wimmer, E. 2009. Inhibition of Hepatitis C Virus IRES-mediated Translation by Oligonucleotides. Virus Res. 2009 Aug 28. [Epub ahead of print] PubMed PMID: 19720092. Wimmer, E., Mueller, S., Tumpey, T. M., J. K. Taubenberger. 2009. Synthetic viruses: a new opportunity to understand and prevent viral disease. Nature Biotechnol. 27(12):1163-72. Books Gromeier, M., Lu, H. H., Mueller, S., Alexander, L., Wimmer, E.. 1997. Attenuated poliovirus as live vaccine. In M. Levine (ed.), New Generation Vaccines. Marcel Dekker Inc., New York. Mueller, S., Wimmer, E. 2000. Picornaviruses as tools of antigen delivery. In A. Cid-Arregui and A. Garcia-Carranca (eds.), Viral Vectors in Gene Therapy and Basic Research. Eaton Publishing, Natick, Massachusetts. Mueller, S., and E. Wimmer. 2007. Picornavirus based expression vectors. In Friedmann, T., Rossi, J. (eds.) Gene Transfer: Delivery and Expression of DNA and RNA. Cold Spring Harbor Press, Cold Spring Harbor, NY Mueller, S., Coleman, J.R., Cello, J., Paul, A., and E. Wimmer. 2007. Synthetic Biology: Synthesis and modification of a chemical called poliovirus. In Luryi, S., Xu, J., Zaslawsky, A. (eds.) Future Trends in Microelectronics: Up the Nano Creek. Wiley & Sons, Inc., Hoboken, New Jersey. In the News 2009 Biologists Spy Close-Up View Of Poliovirus Linked To Host Cell Receptor (Science Daily). 2008 Team Designs Customized "Wimpy" Polioviruses -- A New Path to Vaccines? (Newswise). Fake virus could make safe new vaccines (Reuters). 'Biased' Viruses Suggest New Vaccine Strategy for Polio and Other Diseases (Science Magazine). Silent mutations cause a stir (Nature Reviews Microbiology - News and Analysis). Viral attenuation by design (Nature Biotechnology - News and Views). 2007 Researchers Use Poliovirus To Destroy Neuroblastoma Tumors In Mice (Medical News Today). 2006 'Alien code' leads to faster vaccines (New Scientist). 2000 Study reveals family secret of how viruses enter cells (Purdue News).
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