The Tonge Research Group

Patents

Tonge, P.J., Sullivan, T. and Johnson, F. (2005) “Diphenyl Ether Antimicrobial Compounds”.

  

Book Reviews

Tonge, P.J. (2005) Chemistry and Engineering News 83, 100-101. A light when all other lights go out. Review of ‘Glowing Genes’, author Marc Zimmer.

Book Chapters

Zhang, H., Machutta, C.A. and Tonge, P.J. (2010) Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, volume 8, pp.231–275.  chapter 7, volume 8, pp.231–275.  Fatty Acid Biosynthesis and Oxidation.

Publications

2011

1. Liu, N., Cummings, A.J., England, K., Slayden, R.A.. and Tonge, P.J. (2011) J. Antimicrob. Chemother. in press. Mechanism and Inhibition of the FabI Enoyl-ACP Reductase from Burkholderia pseudomallei. Medline

2. Zhang, Z., Zhou, R., Sauder, J.M., Tonge, P.J., Burley, S.K. and Swaminathan, S. (2011) J. Mol. Biol. accepted. Structural and Functional Studies of Fatty Acyl-Adenylate Ligases from E. coli and L. pneumophila. Medline
   
   
   2010

3. Kumar, K., Awasthi, D., Lee, S.Y., Zanardi, I., Ruzsicska, B., Knudson, S., Tonge, P.J., Slayden, R.A. and Ojima, I. (2010) J. Med. Chem. [Epub]. Novel trisubstituted benzimidazoles, targeting FtsZ, as a new class of antitubercular agents. Medline

4. Lu, H. and Tonge, P.J. (2010) Curr. Opin. Chem. Biol. 14, 467-474. Drug-target residence time: critical information for lead optimization.  Medline

5. Machutta, C.A., Reddy, B.G., Luckner, S.R., Kapilashrami, K., Ruzsicska, B., Simmerling, C., Kisker, C. and Tonge, P.J. (2010) J. Biol. Chem. 285, 6161-9. Slow onset inhibition of bacterial β-ketoacyl-ACP synthases by thiolactomycin. Medline

6. Li, X., Liu, N., Zhang, H., Knudson, S.E., Slayden, R.A. and Tonge, P.J. (2010) Bioorg. Med. Chem. Lett. 20, 6306-9. Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Medline

7. Liu, L., Xu, Y., Shea, C., Fowler, J.S., Hooker, J.M. and Tonge, P.J. (2010). J Med Chem. 53, 2882-91. Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. Medline

8. Luckner, S.R., Liu, N., am Ende, C.W., Tonge, P.J. and Kisker, C. (2010) J. Biol. Chem. 285, 14330-7. A slow tight-binding inhibitor of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis. Medline

9. Lu, H. and Tonge, P.J. (2010) Biochemistry 49, 1281-9. Mechanism and Inhibition of the FabV Enoyl-ACP Reductase from Burkholderia Mallei. Medline

10. Kondo, M, Heisler, .IA., Stoner-Ma, D., Tonge, P.J. and Meech, S.R. (2010) J. Am Chem. Soc. 132, 1452-3. Ultrafast dynamics of protein proton transfer on short hydrogen bond potential energy surfaces: S65T/H148D GFP. Medline
    
    
    2009

11. England, K., am Ende, C.W., Lu, H., Sullivan, T.J., Marlenee, N., Bowen, R.A., Knudson, S.E., Knudson, D.L., Tonge, P.J. and Slayden, R.A. (2009) J. Antimicrob. Chemother. 64, 1052-61. Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia. Medline

12. Kinnings, S.L., Liu, N., Buchmeier,  N., Tonge, P.J., Xie, L. and Bourne, P.E. (2009) PLoS Comput. Biol. 5, e1000423. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. Medline

13. Luckner, S.R., Machutta, C.A., Tonge, P.J. and Kisker, C. (2009) Structure, 17, 1004-1013. Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin. Medline

14. Lu, H. H., England, K., am Ende, C.W. Truglio, J.J., Luckner, S., Marlenee, N., Knudson, S.E., Knudson, D.L., Bowen, R.A., Kisker, C, Slayden, R.A. and Tonge, P.J. (2009) ACS Chem. Biol. 4, 221-231. Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella Tularensis: Residence Time and In Vivo Activity. Medline
    
    
    2008

15. Lu, X., Zhang, H., Tonge, P.J. and Tan, D.S. (2008) Bioorg. Med. Chem. Lett. 18, 5963-5966. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Medline

16. Kruh, N. A., Borgaro, J., Ruzsicska, B. P., Xu, H. and Tonge, P. J. (2008) J. Biol. Chem. 283, 31719-31725. A novel interaction linking the FAS-II and PDIM biosynthetic pathways. Medline

17. Respicio, L., Nair, P.A., Huang Q., Anil, B., Tracz, S., Truglio, J.J., Kisker, C., Raleigh, D.P., Ojima, I., Knudson, D.L., Tonge, P.J. and Slayden, R.A. (2008) Tuberculosis, 88, 420-429. High Content Multiple Feature Transcriptional Profile of Inhibition of Septum Formation in Mycobacterium tuberculosis for Use in Novel Drug Discovery. Medline

18. Karioti, A. Skaltsa, H., Zhang, X., Tonge, P.J., Perozzo, R., Kaiser, M., Franzblau, S.G., Tasdemir, D. (2008) Phytomedicine, 15, 1125-1129. Inhibition of Enoyl-ACP Reductase (FabI) Across Pathogenic Microorganisms by Linear Sesquiterpene Lactones from Anthemis auriculata. Medline

19. Am Ende, C.W., Knudson, S.E., Liu, N., Childs, J., Sullivan, T.J., Boyne, M., Xu, H., Knudson, D.L., Johnson, F., Peloquin, C.A., Slayden, R.A., Tonge, P.J. (2008) Bioorg. Med. Chem. Lett. 18, 3029-3033. Synthesis and in vitro anti-mycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Medline

20. Malo, G.D., Wang, M., Wu, D., Stelling, A.L., Tonge, P.J. and Wachter R.M. (2008) J. Mol. Biol. 378, 869-84. Crystal Structure and Raman Studies of dsFP483, a Cyan Fluorescent Protein from Discosoma striata. Medline

21. Xu, H., Sullican, T.J., Sekiguchi, J., Kirikae, T., Ojima, I., Stratton, C.F., Mao, W., Rock, F.L., Alley, M.R., Johnson, F., Walker, S.G. and Tonge, P.J. (2008) Biochemistry, 47, 4228-36. Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus. Medline

22. Stoner-Ma, D., Jaye, A.A., Ronayne, K. L., Nappa, J., Tonge, P.J. and Meech, S.R. (2008) Chem. Phys. 350, 193-2000. Ultrafast Electronic and Vibrational Dynamics of Stabilized A State Mutants of the Green Fluorescent Protein (GFP): Snipping the Proton Wire. Medline

23. Stoner-Ma, D., Jaye, A.A., Ronayne, K. L., Nappa, J., Meech, S.R. and Tonge, P.J. (2008) J. Am. Chem. Soc. 130, 1227-35. An Alternate Proton Acceptor for Excited State Proton Transfer in Green Fluorescent Protein: Rewiring GFP. Medline

24. Lu, H. and Tonge, P.J. (2008) Acc. Chem. Res. 41, 11-20. Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway. Medline
    
    
    2007

25. Stelling, A., Ronayne, K. L., Nappa, J., Tonge, P.J. and Meech, S.R. (2007) J. Am. Chem. Soc. 129, 15556-64. Ultrafast Structural Dynamics in BLUF Domains: Transient Infrared Spectroscopy of AppA and its Mutants. Medline

26. Tasdemir, D.; Topaloglu, B.; Perozzo, R.; Brun, R.; O'Neill, R.; Carballeira, N. M.; Zhang, X.; Tonge, P. J.; Linden, A.; Ruedi, P. (2007) Bioorg. Med. Chem. 15, 6834-45. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Medline

27. Boyne, M. E.; Sullivan, T. J.; Amende, C. W.; Lu, H.; Gruppo, V.; Heaslip, D.; Amin, A. G.; Chatterjee, D.; Lenaerts, A.; Tonge, P. J.; Slayden, R. A. (2007) Antimicrob. Agents Chemother.51, 3562-7. Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity Inha Inhibitors. Medline

28. Kruh, N. A.; Rawat, R.; Ruzsicska, B. P.; Tonge, P. J. (2007) Protein Sci. 16, 1617-27. Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis. Medline

29. Bonnac, L.; Gao, G. Y.; Chena, L.; Felczaka, K.; Bennetta, E. M.; Xub, H.; Kim, T. S.; Liu, N.; Oh, H. W.; Tonge, P. J.; Pankiewicz, K. W. (2007) Bioorg. Med. Chem. Lett. 17, 4588-91. Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis. Medline

30. Bell, A. F.; Stratton, C. F.; Zhang, X.; Novichenok, P.; Jaye, A. A.; Nair, P. A.; Parikh, S.; Rawat, R.; Tonge, P. J., (2007) J. Am. Chem. Soc. 129, 6425-31. Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis. Medline

31. Tonge, P.J., Kisker, C., and Slayden, R.A. (2007) Current Topics in Medicinal Chemistry, 7, 489-98 . Development of Modern InhA Inhibitors to Combat Drug Resistant Strains of Mycobacterium tuberculosis . Medline

32. Huang, Q., Tonge, P.J. Slayden, R.A., Kirikae, T. and Ojima, I. (2007) Current Topics in Medicinal Chemistry, 7, 527-43 . FtsZ, a Novel Target for Anti-TB Drug Discovery. Medline

33. Kolappan, S. Zwahlen, J., Zhou, R., Truglio, J., Tonge, P.J. and Kisker, C. (2007) Biochemistry 46, 946-53. . Lysine 190 is the Catalytic Base in MenF, the Menaquinone-Specific Isochorismate Synthase from E. Coli: Implications for an Enzyme Family. Medline

34. Zwahlen, J., Kolappan, S., Zhou, R., Kisker, C. and Tonge, P.J. (2007) Biochemistry 46, 954-64 . Structure and Mechanism of MbtI, the Salicylate Synthase from Mycobacterium tuberculosis. Medline
    
    
    2006

35. Kondo, M.; Nappa, J.; Ronayne, K. L.; Stelling, A. L.; Tonge, P. J.; Meech, S. R. (2006) J. Phys. Chem. B. 110, 20107-10 . Ultrafast Vibrational Spectroscopy of the Flavin Chromophore. Medline

36. Stoner-Ma, D.; Melief, E. H.; Nappa, J.; Ronayne, K. L.; Tonge, P. J.; Meech, S. R. (2006) J. Phys. Chem. B. 110, 22009-18 . Proton Relay Reaction in Green Fluorescent Protein (GFP): Polarization-Resolved Ultrafast Vibrational Spectroscopy of Isotopically Edited GFP. Medline

37. Rafi, S., Novichenok, P., Kolappan, S., Zhang, X., Stratton, C.F., Rawat, R., Kisker, C., Simmerling, C. and Tonge, P.J. (2006) J. Biol. Chem. 281, 39285-93 . Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli. Medline

38. Huang, Q., Kirikae, F., Kirikiae, T., Pepe, A., Amina, A., Respicio, L., Slayden, R.A., Tonge, P.J. and Ojima, I. (2006) J. Med. Chem. 49, 463-6. Targeting FtsZ for Antituberculosis Drug Discovery: Noncytotoxic Taxanes as Novel Antituberculosis Agents. Medline

39. Jaye, A.A., Stoner-Ma, D., Matousek, P., Towrie, M., Tonge, P.J. and Meech, S.R. (2006) Photochem. Photobiol. 82, 373-9. Time Resolved Emission Spectra of the Green Fluorescent Protein. Medline

40. Sullivan, T.J., Truglio, J.J., Boyne, M.E., Novichenok, P., Zhang, X., Stratton, C.F., Li, H-J., Kaur, T., Amin, A., Johnson, F., Slayden, R.A., Kisker, C. and Tonge, P.J. (2006) ACS Chemical Biology, 1, 43-53. High Affinity InhA Inhibitors With Activity Against Drug Resistant Strains of Mycobacterium Tuberculosis. Medline

41. Callahan, B.P., Bell, A.F., Tonge, P.J. and Wolfenden, R. (2006) Bioorganic Chemistry, 34, 59-65. A Raman-active competitive inhibitor of OMP decarboxylase. Medline

42. Rafi, S., Cui, G., Song, K., Tonge, P.J. and Simmerling, C. (2006) J. Med. Chem. 49, 4574-80. Predicting the Binding Affinity of Triclosan and Three Triclosan Analogs for FabI, the E. Coli Enoyl Reductase, Using MM-PBSA Calculations. Medline
    
    
    2005
    

43. Stoner-Ma, D., Jaye, A.A., Matousek, P., Towrie, M., Meech, S.R. and Tonge, P.J. (2005) J. Am. Chem. Soc. 127, 2864-5. Observation of Excited State Proton Transfer in Green Fluorescent Protein Using Ultrafast Vibrational Spectroscopy. Medline

44. Wu, J., Bell, A.F. and Tonge, P.J. (2005) J. Am. Chem. Soc. 127, 8424-32. Ring Current Effects in the Active Site of Medium-Chain Acyl-CoA Dehydrogenase Revealed by NMR Spectroscopy. Medline

45. Doll, C., Bell, A.F., Power, N., Tonge, P.J. and Tipton, P.A. (2005) Biochemistry 44, 11440-6. Procatalytic Ligand Strain. Ionization and Perturbation of 8-Nitroxanthine at the Urate Oxidase Active Site. Medline

46. Carlisle-Moore, L., Gordon, C.R., Machutta, C.A., Miller, W.T. and Tonge, P.J. (2005) J. Biol. Chem. 280, 42612-8. Substrate recognition by the human fatty acid synthase. Medline
    
    
    2004

47. Vengris, m., van Stokkum, I.H.M., He, X., Bell, A.F., Tonge, P.J., van Grondelle, R. and Larsen, D.S. (2004) J. Phys. Chem. A. 108, 4587-4598. Ultrafast Excited and Ground-State Dynamics of the Green Fluorescent Protein Chromophore in Solution.

48. Sivaraman, S., Sullivan, T., Johnson, F., Novichenok, P., Cui, G., Simmerling, C. and Tonge, P.J. (2004) J. Med. Chem., 47, 509-518. Inhibition of the Bacterial Enoyl Reductase FabI by Triclosan: A Structure-Reactivity Analysis of FabI Inhibition by Triclosan Analogs. Medline
    
    
    2003

49. Rawat, R., Whitty, A. and Tonge, P.J. (2003) Proc. Natl. Acad. Sci. U.S.A., 100, 13881-13886. The Isoniazid-NAD Adduct is a Slow, Tight-Binding Inhibitor of InhA, the Mycobacterium Tuberculosis Enoyl Reductase; Adduct Affinity and Drug Resistance. Medline

50. Boye, S., Nielsen, S.B., Krogh, H., Nielsen, I.B., Pedersen, U.V., Bell, A.F., He X, Tonge, P.J.and Andersen, L.H. (2003) Phys. Chem. Chem. Phys., 5, 3021-3026. Gas-Phase Absorption Properties of DsRed Model Chromophores

51. Wu,J., Bell, A. F., Luo, L., Stephens, A.W., Stankovich, M. T. and Tonge,P.J. (2003) Biochemistry, 42, 11846-11856. Probing Hydrogen Bonding Interactions in the Active Site of Medium-Chain Acyl-CoA Dehydrogenase using Raman Spectroscopy. Medline

52. Truglio, J.J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P.J. and Kisker, C. (2003) J. Biol. Chem., 278, 42352-42360. Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K₂ Biosynthesis. Medline

53. Sivaraman, S., Hedstrom, L. and Tonge, P.J. (2003) Biochemistry, 42, 4406-13. Structure-Activity Studies of the Inhibition of FabI, the Enoyl Reductase from Escherichia coli, by Triclosan: Kinetic Analysis of Mutant FabIs. Medline

54. Bell, A.F., Stoner-Ma, D., Wachter, R.M. and Tonge, P.J. (2003) J. Am. Chem. Soc. 125, 6919-6926. Light Driven Decarboxylation of Wild-type Green Fluorescent Protein. Medline

55. He, X., Bell, A.F. and Tonge, P.J. (2003) FEBS Lett. 549, 35-38. Ground state isomerization of a model green fluorescent protein chromophore. Medline.

56. Boye, S., Krogh, H., Nielsen, S.B., Pedersen, S.U., Pedersen, U.V., Andersen, L.H., Bell, A.F., He, X. and Tonge, P.J. (2003) Phys. Rev. Lett. 90, 118103. Vibrationally resolved photoabsorption spectroscopy of red fluorescent protein chromophore anions. Medline.
    
    
    2002

57. Bell, A.F., Feng, Y., Hofstein, H.A., Parikh, S., Wu, J., Rudolph, M.J., Kisker, C., Whitty, A. and Tonge, P.J. (2002) Chemistry & Biology, 9, 1247-1255. Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers. Medline

58. Feng, Y., Hofstein, H.A., Zwahlen, J. and Tonge, P.J. (2002) Biochemistry,41, 12883-90. Effect of Mutagenesis on the Stereochemistry of Enoyl-CoA Hydratase. Medline

59. He, X., Bell, A.F. and Tonge, P.J. (2002) Organic Letters, 4, 1523-1526. Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores. Medline.

60. He, X., Bell, A.F. and Tonge, P.J. (2002) J. Phys. Chem ., B106, 6056-6066. Isotopic Labeling and Normal Mode Analysis of a Model Green Fluorescent Protein Chromophore.
    
    
    2001

61. Bell, A.F., Wu, J., Feng, Y. and Tonge, P.J. (2001) Biochemistry, 40, 1725-1733. Involvement of G141 in substrate activation by enoyl-CoA hydratase. Medline.

62. Dai, M., Feng, Y. and Tonge, P.J. (2001) J. Am. Chem. Soc., 123, 506-507. Synthesis of crotonyl-oxyCoA: A mechanistic probe of the reaction catalyzed by enoyl-CoA hydratase. Medline.

63. Bell, A.F., He, X., Ridge, J.P., Hanson, G.R., McEwan, A.G. and Tonge, P.J. (2001) Biochemistry, 40, 440-448. Active site heterogeneity in DMSO Reductase from Rhodobacter capsulatus revealed by Raman spectroscopy. Medline
    
    
    2000

64. llett, J.D., Sabaj, K.M., Stephens, A.W., Bell, A.F., Wu, J., Tonge, P.J. and Stankovich, M.T. (2000) Biochemistry, 39, 13982-13992. Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A: Effects on Reduction Potential, pKa, and Polarization. Medline.

65. Gawlita, E., Lantz, M., Paneth, P., Bell, A.F., Tonge, P.J. and Anderson, V.E. (2000) J. Am. Chem. Soc., 122, 11660-11669. H-Bonding in Alcohols Is Reflected in the C-H Bond Strength: Variation of C-D Vibrational Frequency and Fractionation Factor

66. Parikh, S.L., Xiao, G. and Tonge, P.J. (2000) Biochemistry, 39, 7645-7650. Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid. Medline.

67. Wu, W., Feng, Y., He, X., Hofstein, H.S., Raleigh, D.P. and Tonge, P.J. (2000) J. Am. Chem. Soc. 122, 3987-3994. Stereospecificity of the reaction catalyzed by enoyl-CoA hydratase.

68. Bell, A.F., Xiang, H., Wachter, R.M. and Tonge, P.J. (2000) Biochemistry, 39, 4423-4431. Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy. Medline.

69. Tonge, P.J. (2000) Nat. Struct. Biol., 7, 94-96. Another brick in the wall. Medline.

70. Rudik, I., Bell, A.F., Tonge, P.J. and Thorpe, C. (2000) Biochemistry, 39, 92-101. 4-Hydroxycinnamoyl-CoA: An ionizable probe of the active site of acyl-CoA dehydrogenase. Medline.
    
    
    1999

71. Stankovich, M.T., Sabaj, K.M. and Tonge, P.J. (1999) Arch. Biochem. Biophys., 370, 16-21. Structure/function of medium chain acyl-CoA dehydrogenase: The importance of substrate polarization.

72. Parikh, S., Moynihan, D.P., Xiao, G. and Tonge, P.J. (1999) Biochemistry, 38, 13623-13634. Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium Tuberculosis. Medline.

73. Hofstein, H.S., Feng, Y., Anderson, V.E. and Tonge, P.J. (1999) Biochemistry, 38, 9508-9516. Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase. Medline.

74. Stewart, M., Parikh, S., Xiao, G., Tonge, P.J. and Kisker, C. (1999) J. Mol. Biol.,290, 859-865. Structural basis for the mechanism of action of triclosan. Medline.
    
    
    1998

75. Wu, W-J., Tonge, P.J. and Raleigh, D.P. (1998) J. Am. Chem. Soc., 120, 9988-9994. Stereospecific 1H and 13C NMR assignments of crotonyl-coenzyme A and hexadienoyl-coenzyme A: conformational analysis and comparison with protein:CoA complexes.
    
    
    1997

76. Tonge, P.J., Carey, P.R. and Fausto, R . (1997) J. Chem. Soc. Faraday Trans., 93, 3619-3625. Molecular structure of S-ethyl thioacrylate. Combined vibrational spectroscopic and ab initio SCF-MO study.

77. Clarkson, J., Tonge, P.J., Taylor, K.L., Dunaway-Mariano, D. and Carey, P.R. (1997) Biochemistry, 36, 10192-10199. A Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.

78. Wu, W-J., Anderson, V.E., Raleigh, D.P. and Tonge, P.J. (1997) Biochemistry, 36, 2211-2220. Structure of hexadienoyl-CoA bound to enoyl-CoA hydratase determined by transferred NOE measurements: mechanistic predictions based on the X-ray structure of 4-chlorobenzoyl-CoA dehalogenase. Medline.
    
    
    1996

79. P opov, S., Dubrovsky, L., Lee, M-A., Pennathur, S., Haffer, O., Al-Abed, Y., Tonge, P.J., Ulrich, P., Rexach, M., Blobel, G., Cerami, A.C. and Bukrinsky, M. (1996) Proc. Natl. Acad. Sci. USA, 93, 11859-11864. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation

80. Doran, J.D., Tonge, P.J., Mort, J.S. and Carey, P.R. (1996) Biochemistry, 35, 12487-12494. Deacylation and reacylation for a series of acyl cysteine proteases, including acyl groups derived from novel chromophoric substrates.

81. Tonge, P.J., Fausto, R. and Carey, P.R. (1996) J. Mol. Struct., 379, 135-142. FTIR studies of hydrogen bonding between a ,b -unsaturated esters and alcohols.

82. Moore A.N.J, Vakos H, Neville T.A.M, Tonge P.J., Arya P, Burton G.W. (1996) Biotechnology Techniques, 10, 523-528. A quick method for purifying bile salt-activated lipases.
    
    
    1995

83. Tonge, P.J., Anderson, V.E., Fausto, R., Kim, M., Pusztai-Carey, M. and Carey, P.R. (1995) Biospectroscopy, 1, 387-394. Localized electron polarization in a substrate analog binding to the active site of enoyl-CoA hydratase: Raman spectroscopic and conformational analyses of rotamers of hexadienoyl thiolesters.

84. Doran, J.D., Tonge, P.J., Carey, P.R. and Arya, P. (1995) Bioorganic and Medicinal Chemistry Letters, 5, 2381-2384. Synthesis of chromophoric dipeptides as substrates for papain.

85. Taylor, K.L., Liu, R.Q., Liang, P.H., Price, J., Dunaway-Mariano, D., Tonge, P.J., Clarkson, J. and Carey, P.R. (1995) Biochemistry, 34, 13881-13888. Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.

86. Carey, P.R. and Tonge, P.J. (1995) Acc. Chem. Res., 28, 8-13. Unlocking the secrets of enzyme power using Raman spectroscopy.
    
    
    1994

87. Fausto, R., Tonge, P.J. and Carey, P.R. (1994) J. Chem. Soc. Faraday Trans., 90, 3491-3503. Molecular structures of cis- and trans-S-ethyl thiocrotonate.

88. D'Ordine, R.L., Bahnson, B.J., Tonge, P.J. and Anderson, V.E. (1994) Biochemistry, 33, 14733-14742. Enoyl-CoA hydratase catalyzed exchange of the a -protons of CoA thiolesters: A model for an enolized intermediate in the enzyme catalyzed elimination?

89. D'Ordine, R.L., Tonge, P.J., Carey, P.R. and Anderson, V.E. (1994) Biochemistry, 33, 12635-12643. Electronic rearrangement induced by substrate analog binding to the enoyl-CoA hydratase active site: Evidence for substrate activation.

90. Doran, J.D., Tonge, P.J., Kim, M. and Carey, P.R. (1994) Photochemistry and Photobiology, 60, 432-434. Facile characterization of the spectra of cis and trans photoisomers in a mixture of acyl-enzymes by raman difference spectroscopy.

91. Fausto, R., Martins, A.G., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Phys. Chem. 98, 3592-3596. Rotational isomerism in CH3CH2C(=S)SR (R=CH3, C2H5): a combined vibrational spectroscopic and ab initio study.

92. Fausto, R., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Mol. Struct. 324, 113-122. Rotational isomers of N-(b -phenylpropionyl)alanine ethyl dithioester: a Raman spectroscopic and MO study.

93. Fausto, R., Martins, A.G., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Mol. Struct. 323, 59-69. Rotational isomerism in CH3C(=S)SCH3 and CH3(C=S)SC2H5: a combined vibrational spectroscopic and ab initio study.
    
    
    1993

94. Tonge, P.J., Carey, P.R., Callender, R., Deng, H., Ekiel, I. and Muhandiram, D.D. (1993) J. Am. Chem. Soc. 115, 8757-8762. Characterization of trans and cis-5-methylthienylacryloylchymotrypsin using Raman difference spectroscopy, NMR and kinetics: Carbonyl environment and reactivity.

95. Tonge, P.J. and Carey, P.R. (1993) Advances in Spectroscopy 20, 129-161. Biomolecular Spectroscopy Part A, ed. Clark, R.J.H. and Hester, R.E. Raman, resonance Raman and FTIR spectroscopic studies of enzyme-substrate complexes.

96. Curtis, R.D., Tonge, P.J., Smith, I.C.P. and Jarrell, H.C. (1993) J. Magn. Reson. 102A, 110-113. DePakeing of dipolar-chemical shift NMR spectra.
    
    
    1992

97. Tonge, P.J, and Carey, P.R. (1992) Biochemistry 31, 9122-9125. Forces, bond lengths and reactivity; fundamental insight into the mechanism of enzyme catalysis.

98. Tonge, P.J., Carey, P.R. and Anderson V.E. (1992) J. Am. Chem. Soc. 114, 8738-8739. Multiple forms of acetyldithio-coenzyme A binding to citrate synthase; resonance Raman evidence.

99. Tonge, P.J., Gour-Salin, B., Lachance, P., Storer, A.C. and Carey, P.R. (1992) Biophys. J. 63, 191-196. Resonance Raman spectroscopic and kinetic consequences of a nitrogen-sulphur enzyme-substrate contact in a series of dithioacylpapains.
    
    
    1991

100. Tonge, P.J., Pusztai, M., White, A.J., Wharton, C.W. and Carey, P.R. (1991) Biochemistry 30, 4790-4795. Resonance Raman and FTIR spectroscopic studies of the acyl carbonyl group in [3-(5-Methyl-2-thienyl)acryloyl]-chymotrypsin: evidence for artifacts in the spectra obtained by both techniques.

101. Tonge, P.J., Menard, R., Storer, A.C., Ruzsicska, B.P. and Carey, P.R. (1991) J. Am. Chem. Soc. 113, 4297-4303. Markedly different acyl-papain structures deacylate at similar rates: Resonance Raman spectroscopic and kinetic evidence.
     
     
     1990

102. Tonge, P.J. and Carey, P.R. (1990) Biochemistry 29, 10723-10727. Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity.

103. Carey, P.R. and Tonge. P.J. (1990) Chem. Soc. Rev. 19, 97-120. Chemistry of enzyme-substrate complexes revealed by resonance Raman spectroscopy.
     
     
     1989

104. Tonge, P.J. and Carey, P.R. (1989) Biochemistry 28, 6701-6709. Direct observation of the titration of substrate carbonyl groups in the active site of a-chymotrypsin by resonance Raman spectroscopy.

105. Tonge, P.J., Lee, H., Sans Cartier, L.R., Ruzsicska, B.P. and Carey, P.R. (1989) J. Am. Chem. Soc. 111, 1496-1497. Striking changes observed in key acyl-enzyme linkages by resonance Raman experiments near 77 K.

106. Sans Cartier, L.R., Tonge, P.J. and Carey, P.R. (1989) Indian Journal of Physics. 63, 5170-5179. Resonance Raman studies of enzyme-substrate intermediates at cryogenic temperatures: construction of a cryostat-based U.V. resonance Raman system.

107. Tonge, P.J. and Carey, P.R. (1989) J. Mol. Liquids. 42, 195-212. Resonance Raman and absorption spectroscopic characterization of the chemically engineered enzyme thiolsubtilisin: comparison with a natural thiolenzyme.

108. Tonge, P.J., Moore, G.R. and Wharton, C.W. (1989) Biochem. J. 258, 599-605. Fourier-Transform infra-red studies of the alkaline isomerization of mitochondrial cytochrome c and the ionization of carboxylic acids.
     
     
     1985

109. Tonge, P.J. and Wharton, C.W. (1985) Biochem. Soc. Trans. 13, 929-930. Observation of carbonyl stretch vibrations in acyl-chymotrypsins by using Fourier-Transform infra-red spectroscopy.

110. Tonge, P.J., Wharton, C.W., Szawelski, R.J., Killough, P.M. and Hester, R.E. (1985) Biochem. Soc. Trans. 13, 930-931. Ultra-violet resonance Raman spectroscopy of a highly specific acyl-papain.