Mutations in the gene cdk2, which encodes a cyclin-dependent kinase, have been implicated in breast cancer. You have cloned out the cdk2 gene from affected members of one family with a history of breast cancer (sequence labelled cdk2-mut).
Compare the sequences of the wild type and mutant cdk2 genes. What is the nucleotide change in the mutant allele? What change does that cause in the amino acid sequence?
>cdk2 wild type cttcatggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaagccagaaacaagttga cgggagaggtggtggcgcttaagaaaatccgcctggacactgagactgagggtgtgcccagtactgccatccgagagatc tctctgcttaaggagcttaaccatcctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggt ttttgaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcctcttcccctcatcaaga gctatctgttccagctgctccagggcctagctttctgccattctcatcgggtcctccaccgagaccttaaacctcagaat ctgcttattaacacagagggggccatcaagctagcagactttggactagccagagcttttggagtccctgttcgtactta cacccatgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattattccacagctgtggaca tctggagcctgggctgcatctttgctgagatggtgactcgccgggccctattccctggagattctgagattgaccagctc ttccggatctttcggactctggggaccccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaag tttccccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacggagcttgttatcgcaaa tgctgcactacgaccctaacaagcggatttcggccaaggcagccctggctcaccctttcttccaggatgtgaccaagcca gtaccccatcttcgactctgatagccttcttgaagcccccagccctaatctcaccctctcctccagtgtgggcttgacca ggcttgcgcttgggctatttggactcaggtgggccctctgaacttgccttaaac >cdk2 mutant cttcatggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaagccagaaacaagttga cgggagaggtggtggcgcttaagaaaatccgcctggacactgagactgagggtgtgcccagtactgccatccgagagatc tctctgcttaaggagcttaaccatcctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggt ttttgaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcctcttcccctcatcaaga gctatctgttccagctgctccagggcctagctttctgccattctcatcgggtcctccaccgagaccttaaacctcagaat ctgcttattaacacagagggggccatcaagctagcagactttggactagccagagcttttggagtccctgttcgtactta cacccatgaggtggtgaccctgtggtaccgagctcctaaaatcctcctgggctgcaaatattattccacagctgtggaca tctggagcctgggctgcatctttgctgagatggtgactcgccgggccctattccctggagattctgagattgaccagctc ttccggatctttcggactctggggaccccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaag tttccccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacggagcttgttatcgcaaa tgctgcactacgaccctaacaagcggatttcggccaaggcagccctggctcaccctttcttccaggatgtgaccaagcca gtaccccatcttcgactctgatagccttcttgaagcccccagccctaatctcaccctctcctccagtgtgggcttgacca ggcttgcgcttgggctatttggactcaggtgggccctctgaacttgccttaaac
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